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Annexin A1 (ANXA1) deficiency reduced the 7‐day survival rate and exacerbated CLP‐induced neurobehavioral changes in septic mice. Mice were divided into four groups: WT, CLP, ANXA1 (−/−), and ANXA1 (−/−) + CLP. (A) The survival rate was analyzed at day 0, 1, 2, 3, 4, 5, 6, and 7 post‐operation; (B) cognitive function at days 3, 5, and 7 after the operation was assessed using the Y‐maze test (***p < 0.005 vs. WT group; ### p < 0.005 vs. ANXA1 (−/−) group; && p < 0.01 vs. CLP group).
