Table 1.
The VIP score and fold change in lipid-soluble metabolites significantly differentially expressed between lung tissue of 7-day-old male spring rat with and without prenatal PS-MPs exposure.
| Metabolites | VIP Score * | Fold Change † | p |
|---|---|---|---|
| PC 35:4 | 1.19 | 1.37 × 10−5 | 0.021 |
| PE 8:0_28:4 | 0.91 | 1.71 × 10−5 | 0.028 |
| LPC 30:1 | 0.74 | 46,919 | 0.030 |
| SM 32:3;O3 | 1.42 | 1.23 × 10−5 | 0.032 |
| Cer 24:0;O2/14:1 | 2.09 | 9.04 × 10−6 | 0.041 |
| PC 17:4_21:4 | 1.77 | 1.33 × 10−5 | 0.041 |
| PC 10:0_26:6 | 1.25 | 1.07 × 10−5 | 0.041 |
| TG 36:2_16:4_16:4 | 2.48 | 1.02 × 10−5 | 0.041 |
| PC 42:11 | 1.70 | 1.44 × 10−5 | 0.041 |
| PC O-16:1_24:6 | 1.11 | 8.22 × 10−6 | 0.041 |
| SL 15:2;O/18:5 | 1.38 | 1.16 × 10−5 | 0.042 |
| PC O-20:0_28:2 | 3.40 | 7.93 × 10−6 | 0.046 |
| NAGlySer 24:6;O(FA 19:5) | 1.40 | 1.15 × 10−5 | 0.048 |
| TG 18:5_21:5_18:0;O4 | 1.62 | 1.00 × 10−5 | 0.048 |
* VIP scores were obtained from partial least squares discriminant analysis (PLS-DA). † Fold changes were calculated by dividing the value of metabolites in rats with prenatal PS-MPs exposure by control group. VIP, variable importance in projection; FDR, false discovery rate; PC, phosphatidylcholine; PE, phosphatidylethanolamine; LPC, lysophosphatidylcholine; SM, sphingomyelin; Cer, ceramide; TG, triglyceride; SL, saccharolipid; NAGly, N-acyl glycine; Ser, serine. Each group comprised three animals.