Table 2.
The aqueous metabolites differentially expressed between lung tissue of seven-day-old male offspring rat with and without prenatal PS-MPs exposure.
| Aqueous Metabolites | |||
|---|---|---|---|
| Metabolites | VIP Score * | Fold Change | p |
| Cytosine | 1.76 | 5220.8 | <0.001 |
| 2′,3′-Dideoxyinosine | 1.92 | 0.000177 | 0.003 |
| N-Methylisoleucine | 1.35 | 4062.9 | 0.008 |
| Hypoxanthine | 1.23 | 3840.1 | 0.013 |
| Adenosine 5′-monophosphate | 2.23 | 0.000141 | 0.015 |
| Raffinose | 1.35 | 3543 | 0.016 |
| Succinic acid | 1.08 | 3228.9 | 0.016 |
| Creatinine | 1.41 | 4866.1 | 0.017 |
| 2′-Deoxycytidine | 1.05 | 3884.5 | 0.026 |
| 3-Methylcytidine | 1.5 | 0.000238 | 0.026 |
| alpha-Galactosamine-1-phosphate | 0.78 | 1881.3 | 0.027 |
| Hydromorphone | 1.12 | 3913.5 | 0.027 |
| Pyroglutamic acid (5-oxoproline) | 2.00 | 5696.8 | 0.027 |
| Methohexital | 0.74 | 2085.8 | 0.031 |
| Guanine | 1.64 | 4765.5 | 0.032 |
| Phenylacetylglutamine | 1.05 | 2939.6 | 0.032 |
| Betaine | 1.02 | 3131.1 | 0.034 |
| Riboflavin | 1.47 | 4449.9 | 0.035 |
| Glutamine | 1.91 | 5635.2 | 0.038 |
| N8-Acetylspermidine | 1.39 | 3217.7 | 0.041 |
* Variable importance in projection (VIP) scores were obtained from PLS-DA. Fold changes were calculated by dividing the value of metabolites in seven-day-old offspring rats with prenatal PS-MPs exposure by the value of those without prenatal PS-MPs exposure. Each group comprised three animals.