Table 9.

Collagen index changes at the dermis layer from baseline to week 4 for the two studied groups. (t-test Student vs. baseline ** p < 0.01, *** p < 0.001).

	Collagen Index
	CpLfe		Placebo
Timing	Average ± SD	Average ∆% vs. Baseline	Average ± SD	Average ∆% vs. Baseline
Baseline	44.2 ± 1.6		47.2 ± 1.9
After 2-week treatment (T2w)	45.6 ± 0.8	3.4% **	47.8 ± 2.4	1.3%
After 4-week treatment (T4w)	47.9 ± 0.9	8.5% ***	48.3 ± 2.3	2.1%

All differences between groups were statistically significant p < 0.05 (ANOVA test).