Table 2.

Meta-regression analysis for different parameters

Parameter		Sensitivity (95% CI)	Specificity (95% CI)
Type of research	Prospective (4 studies)	69% (48–90%)	99% (97–100%)
	Retrospective (9 studies)	80% (69–90%)	98% (94–100%)
	Meta-regression P-value	0.13	0.00
Sequencing conditions	BGISEQ (7 studies)	72% (57–86%)	98% (93–100%)
	Others (6 studies)	82% (70–94%)	99% (97–100%)
	Meta-regression P-value	0.07	0.27
Homogenization	Yes (7 studies)	67% (53–80%)	99% (95–100%)
	No (6 studies)	86% (77–94%)	99% (95–100%)
	Meta-regression P-value	0.00	0.07
Sample pre-treatment	With bead-beating (6 studies)	82% (77–94%)	99% (97–100%)
	Without bead-beating (7 studies)	72% (57–86%)	98% (93–100%)
	Meta-regression P-value	0.87	0.02