Table 1. .
Sample characteristics (MC and NC matches)
| Measure | Mutation carrier (N = 69) a | Noncarrier match (N = 52) b | χ 2 | df | p value | |
|---|---|---|---|---|---|---|
| MC CDR = 0/NC match 1 | Sex (M/F) | 36/33 | 23/29 | 0.749 | 1 | 0.387 |
| Family mutation (PS1, PS2, APP) n (%) | 48 (70%) | 36 (69%) | 0.381 | 2 | 0.827 | |
| 11 (16%) | 10 (19%) | |||||
| 10 (14%) | 6 (11%) | |||||
| APOE ϵ4 carriers/noncarriers | 17/52 | 14/38 | 0.081 | 1 | 0.776 | |
| Median [min, max] | Mann-Whitney U | z | p value | |||
| Age (years) | 33.2 [18.0, 52.6] | 34.4 [21.5, 52.8] | 4,030 | −0.935 | 0.350 | |
| Education (years) | 16 [9, 24] | 16 [10, 21] | 4,198 | −0.06 | 0.956 | |
| EYO | −15.1 [−36.0, −0.5] | −15.3 [−31.5, −0.8] | 4,098 | −0.579 | 0.563 | |
| CCSc | −0.03 [−1.35, 1.64] | 0.10 [−1.14, 1.14] | 3,817 | −1.570 | 0.116 | |
| Average FD of retained frames | 0.085 [0.035, 0.223] | 0.074 [0.039, 0.174] | 4,561 | 1.840 | 0.066 | |
| Remaining minutes of the scan | 4.7 [3.2, 6.3] | 4.3 [3.2, 17.3] | 4,415.5 | 1.079 | 0.281 | |
| Measure | Mutation carrier (N = 32) | Noncarrier match (N = 17) | χ 2 | df | p value | |
| MC CDR = 0.5/NC match 2 | Sex (M/F) | 13/19 | 3/14 | 2.666 | 1 | 0.103 |
| Family mutation (PS1, PS2, APP) n (%) | 25 (78%) | 8 (47%) | 5.049 | 2 | 0.080 | |
| 1 (3%) | 2 (12%) | |||||
| 6 (19%) | 7 (41%) | |||||
| APOE ϵ4 carriers/noncarriers | 9/23 | 3/14 | 0.659 | 1 | 0.417 | |
| Median [min, max] | Mann-Whitney U | z | p value | |||
| Age (years) | 48.5 [30.1, 65.6] | 49.7 [29.1, 62.6] | 824 | 0.494 | 0.622 | |
| Education (years) | 13.5 [6, 19] | 14 [9, 18] | 733.5 | −1.398 | 0.162 | |
| EYO | 1.7 [−14.2, 10.4] | 1.7 [−14.5, 8.9] | 837 | 0.767 | 0.443 | |
| CCSd | −1.55 [–3.09, −0.11] | 0.01 [−1.24, 1.53] | 487 | −5.148 | <0.001*** | |
| Average FD of retained frames | 0.106 [0.052, 0.194] | 0.091 [0.045, 0.176] | 850 | 1.040 | 0.299 | |
| Remaining minutes of the scan | 6.6 [3.4, 10.1] | 4.6 [4.1, 16.7] | 855.5 | 1.156 | 0.248 | |
| Measure | Mutation carrier (N = 20) | Noncarrier match (N = 15) | χ 2 | df | p value | |
| MC CDR ≥ 1/NC match 3 | Sex (M/F) | 9/11 | 7/8 | 0.010 | 1 | 0.922 |
| Family mutation (PS1, PS2, APP) n (%) | 17 (85%) | 12 (80%) | 6.276 | 2 | 0.043* | |
| 0 (0%) | 3 (20%) | |||||
| 3 (15%) | 0 (0%) | |||||
| APOE ϵ4 carriers/noncarriers | 5/15 | 5/10 | 0.292 | 1 | 0.589 | |
| Median [min, max] | Mann-Whitney U | z | p value | |||
| Age (years) | 50.8 [35.8, 67.0] | 55.4 [36.4, 69.5] | 341 | −0.617 | 0.538 | |
| Education (years) | 12 [8, 18] | 14 [11, 26] | 292.5 | −2.270 | 0.023* | |
| EYO | 4.3 [−1.8, 14.9] | 4.9 [−3.3, 20.8] | 372 | 0.383 | 0.702 | |
| CCSe | −2.71 [−3.43, −2.15] | −0.05 [−0.64, 1.07] | 105 | −4.561 | <0.001*** | |
| Average FD of retained frames | 0.126 [0.054, 0.205] | 0.113 [0.045, 0.192] | 380 | 0.650 | 0.516 | |
| Remaining minutes of the scan | 4.5 [3.4, 10.0] | 4.8 [3.2, 11.4] | 316 | −1.451 | 0.147 |
a
Removed one participant due to non-other participants existing from the same site.
b
Removed one participant due to non-other participants existing from the same site.
c
Missing two participants.
d
Missing two participants.
e
Missing six participants.
Medians and Mann-Whitney test statistics reported (Shapiro-Wilk test of normality p < 0.001)
df, degrees of freedom; CDR, Clinical Dementia Rating; M, male; F, female; EYO, estimated years from expected symptom onset; CCS, cognitive composite score.
*p < 0.05, **p < 0.01, ***p < 0.001.