Table 2. .

Group-level hub disruption (using the metrics in NC match 1 as a baseline) across CDR stages in the MC and across age in the NC (FDR-adjusted)

Strength (S)
	Group	κS	F(1, 244)	p	R 2
MC	CDR = 0	−5.6	59.1	<0.001	0.20
	CDR = 0.5	−9.6	118.1	<0.001	0.33
	CDR ≥ 1	−16.7	192.2	<0.001	0.44
NC	Match 2	−0.8	0.78	0.38	0.003
	Match 3	−1.3	1.46	0.28	0.006
Participation coefficient (Pc)
	Group	κS	F(1, 244)	p	R 2
MC	CDR = 0	3.3	17.8	<0.001	0.07
	CDR = 0.5	1.7	2.5	0.19	0.01
	CDR ≥ 1	−1.6	1.0	0.34	0.44
NC	Match 2	2.1	4.7	0.08	0.02
	Match 3	−1.0	0.9	0.34	0.003
Within-module strength Z-score (Z)
	Group	κS	F(1, 244)	p	R 2
MC	CDR = 0	−5.0	12.6	<0.001	0.05
	CDR = 0.5	−7.2	15.5	<0.001	0.06
	CDR ≥ 1	−12.7	22.1	<0.001	0.08
NC	Match 2	−2.1	1.6	0.21	0.01
	Match 3	−3.3	2.9	0.11	0.01