Figure 1.

RAGE expression was upregulated in embryonic RAGE transgenic (TG) murine lung tissue, and hematoxylin and eosin stains were used to evaluate lung morphology. H&E-stained sections revealed the marked simplification of E0-E18.5 RAGE TG lungs (C,F) compared to controls (A,D). An intermediate phenotype was observed in E15.5-E18.5 TG lungs (B,E), in which tissue reduction resulted in fewer distal compartments surrounded by thickened alveolar walls. All images are representative. Original magnifications of 100× (A–C) and 200× (D–F) are shown, with scale bars representing 200 µm (A–C) or 100 µm (D–F).