Figure 2.

Differential expression of BCL-2 family members (BCL-W and BID) and mitochondrial proteins (SMAC and HTRA2) in RAGE TG mice. We discovered significantly less anti-apoptotic BCL-W (A) and significantly elevated levels of pro-apoptotic molecules including BID, SMAC, and HTRA2 (B–D) in E0-E18.5 RATE TG mouse lungs compared to the controls. While BLC-W and SMC were unchanged in E15.5-E18.5 RAGE TG mice, BID was markedly upregulated (B) and HTRA2 was significantly downregulated (D) compared to the controls. Significant differences when comparing the protein abundance in lung homogenates are noted as * p ≤ 0.05.