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. 2024 Dec 21;46(12):14453–14463. doi: 10.3390/cimb46120867

Figure 3.

Figure 3

Differential expression of tumor necrosis factor superfamily and insulin-like growth factor-binding proteins (IGFBPs) in RAGE TG mice. Among the TNF family members, there was no significant difference in TNFRSF21 or Fas/FasL in E15.5-18.5 RAGE TG mice; however, Trail R2 was markedly increased in E15.5-18.5 RAGE TG mice compared to controls (A–C). Each of these pro-apoptotic factors (TNFRS21, Fas/FasL, and Train R2) were significantly increased in E0-18.5 RAGE TG mice compared to the controls (A–C). We discovered decreased IGFBP4 and IGFBP6 levels in E15.5-18.5 RAGE TG mice and significantly decreased IGFBP3 and IGFBP4 levels in E0-18.5 RAGE TG mice compared to the controls (D–F). Significant differences when comparing the protein abundance in lung homogenates are noted as * p ≤ 0.05.