Figure 5.

Differential expression of inhibitors of apoptosis proteins (IAPs) and heat shock proteins (HSPs) in RAGE TG mice. We detected elevated levels of XIAP and Survivin in both E15.5-18.5 and E0-18.5 RAGE TG mice compared to the controls (B,C), suggesting mechanisms that possibly attempt to prevent excessive cellular apoptosis. We similarly detected elevated levels of cIAP-2 in E0-18.5 RAGE TG mice compared to the controls (A). While HSP27 was unchanged in E0-18.5 RAGE TG mice, this molecular chaperone that protects cells from apoptosis was decreased in E15.5-18.5 RAGE TG mice compared to the controls (D). Significant differences when comparing the protein abundance in lung homogenates are noted as * p ≤ 0.05.