TABLE 2.

Results of Mendelian randomization analysis of statin medication on gut microbiota abundance.

Gut microbiota	nSNP	p-value	Beta	Se	Beta 95% IC	Pleiotropy p-value	MR-PRESSO p-value
Parabacteroides						0.4479	0.4145
IVW	54	0.0013	−0.2745	−0.0594	(−0.4422, −0.1068)
MR-Egger	54	0.0868	−0.4694	−0.1012	(−0.9965, 0.0577)
Weighted median	54	0.0083	−0.3349	−0.1021	(−0.5839, −0.0859)
Ruminococcaceae UCG-009						0.3730	0.7885
IVW	44	0.0057	−0.1904	−0.0919	(−0.3255, −0.0553)
MR-Egger	44	0.8753	0.0421	−0.1454	(−0.4819, 0.5662)
Weighted median	44	0.1676	−0.1323	−0.1129	(−0.3202, 0.0556)
Coprococcus 1						0.8426	0.1928
IVW	45	0.0154	−0.1212	−0.0491	(−0.2194, −0.0231)
MR-Egger	45	0.6736	−0.0833	−0.0571	(−0.4686, 0.3019)
Weighted median	45	0.1465	−0.0987	−0.0585	(−0.2320, 0.0345)
Desulfovibrio						0.6778	0.5888
IVW	48	0.0255	0.2452	−0.0819	(0.0299, 0.4606)
MR-Egger	48	0.8151	0.0907	−0.0906	(−0.6652, 0.8467)
Weighted median	48	0.1304	0.2491	−0.0543	(-0.0073, 0.5720)
Ruminococcaceae UCG010						0.1888	0.2823
IVW	45	0.0385	−0.1149	−0.0559	(−0.2238, −0.0060)
MR-Egger	45	0.4552	0.1614	−0.0216	(−0.2584, 0.5812)
Weighted median	45	0.0606	−0.1464	−0.0270	(−0.2995, 0.0065)
Veillonellaceae						0.5889	0.4778
IVW	45	0.0400	−0.0970	−0.0560	(−0.2238, 0.0060)
MR-Egger	45	0.9994	−0.0001	0.0048	(−0.2584, 0.5812)
Weighted median	45	0.3321	−0.0658	−0.0612	(−0.2995, 0.0065)