Table 3.
Literature review of 41 studies on malignant proliferating trichilemmal tumor of the scalp covering 60 cases, including the current study, over the past 24 years (2000–2024) in PubMed.
| Year [Ref #] |
Age | Case # /Sex (F/M) |
Duration (mo, y) | Size (cm) |
Local Recur (#) | Metastasis /Site (#) |
F-U (mo, y) (#) |
|---|---|---|---|---|---|---|---|
| 2000 [3] | 61 | 1/F | 20 y | 16.0 | NA | Brain | 12 mo/died |
| 2001 [4,5] | 51 | 1/F | 6 y | 1.2 | NA | None | NA |
| 32 | 1/M | 1 y | 8.0 | None | LN, Brain | 6 mo | |
| 2002 [6] | 60 | 1/F | 4 y | 5.0 | NA | None | L to F-U |
| 2003 [7] | 69 | 1/F | 2 y | 2.0 | Recur | LN | 8 mo |
| 2004 [8] | 41–87 | 11/F, 3/M | 1 mo–20 y | 1.0–9.0 | Recur (3) | LN (1) | 3 mo–8.5 y Died (2) Ϯ |
| 2005 [9] | 33 | 1/M | 1 y | 10.0 | None | None | ~1.5 y |
| 2006 [10] | 54 | 1/F | 3 y | 3.0 | None | None | 2 y |
| 2007 [11,12] | 32 | 1/F | NA | 12 | Recur | LN | 4 mo |
| 19 | 1/M | NA | 5.0 | Recur | BOS, CS, Lung | 5 y/died | |
| 50 | 1F | 3 mo | 6.7 | NA | LN | NA | |
| 2008 [13,14,15] | 72 | 1F | 10 y | 2.0 (recur) | Recur | None | 32 mo |
| 32 | 1M | 1 y | 2.5 | None | LN | 9 mo/died Ϯ | |
| 76 | 1F | Recent | 2.0 | None | None | 11 mo | |
| 2009 [16,17] | 85 | 1F | 1 y | 15.0 | None | None | 14 mo |
| 58 | 1F | 2 mo | 5.5 | NA | None | L to F-U | |
| 2010 [18,19] | 58 | 1F | 1 y | 3.2 | NA | None | NA |
| 41 | 1F | 1 y | NA | NA | None | NA | |
| 51 | 1F | NA | 16 | Recur | None | 54 mo | |
| 53 | 1M | Rapid | 20 | Recur | Brain | 9 mo/died | |
| 2011 [20,21] | 65 | 1F | 9 y | 2.0 | None | None | 6 mo |
| 57 | 1F | Many y | 7.0 | NA | None | L to F-U | |
| 2012 [22,23] | 73 | 1F | 3 y | 6.0 | NA | None | L to F-U |
| 25 | 1F | 1 y | 4.0 | None | None | 1 y | |
| 2013 [24] | 62 | 1F | NA | NA | None | Left pleura | 3 y |
| 2014 [25,26,27] | 65 | 1F | 4 mo | 3.0 | NA | None | NA |
| 32 | 1M | 8 mo | 15.0 | NA | None | F-U | |
| 26 | 1F | 1 y | 6.0 | Recur | LN | 1 mo | |
| 2015 [28,29,30] | 67 | 1M | 3 mo | 3.0 | None | None | 6 mo |
| 48 | 1F | NA | 4.0 (recur) | Recur | None | ~2 y | |
| 65 | 1M | 40 y | NA | None | LN, Pancreas | 15 mo | |
| 2016 [31,32,33] | 61 | 1M | 15 y | 15.0 | NA | None | L to F-U |
| 29 | 1M | 7 y | 30.0 | NA | Lung | 2 mo/died | |
| 42 | 1M | 11 y | 22.0 | Recur | None | 28 mo | |
| 2017 [34] | 64 | 1F | 18 mo | 12.0 | None | None | 3 mo |
| 2018 [35] | 56 | 1F | 1 y | 1.8 | Recur | None | 6 mo |
| 2019 [36] | 68 | 1F | 20 y | ~15.0 | NA | None | NA |
| 2020 [37] | Old | 2F | NA | NA | None | None | 2 y |
| 2021 [38] | 46 | 1F | Many y | 1.5 | NA | None | F-U |
| 2022 [39,40] | 85 | 1M | 2 y | 6.8 | None | None | 7 mo |
| 69 | 1M | 1 y | 2.0 | Recur | LN, Lung | 26 mo/died | |
| 55 | 1F | 1.5 y | 11.0 | None | None | 10 mo | |
| NA | 1 (NA) | NA | 10.0 | Recur | None | 2 mo/died | |
| 2023 [41] | 86 | 1F | Several y | 4.0 | None | None | 2 y |
| 2024 [42] | 87 | 1M | NA | 6.0 | None | None | 6 mo |
| Current c | 64 | 1F | 1 y | 2.0 | None | None | 10 mo |
Ref: reference; #: number of cases; F: female; M: male; mo: month(s); y: year(s); cm: centimeter(s); NA: not available; LN: lymph node; BOS: base of skull; CS: cistern sinus; L to F-U: lost to follow-up; C: case. Ϯ Total two patients died of diseases other than MPTT.