Comparison of Synechocystis SPP with Two HAD Superfamily Phosphatases.
The core and cap domains are colored in purple and pink, respectively, in the open conformation of SPP and the two proteins with the highest DALI scores, a phosphatase, whose substrate is unknown, from T. maritima (Protein Data Bank code 1nf2) and phosphoglycolate phosphatase from T. acidophilum (Protein Data Bank code 1kyt). The conserved hydrolase fold includes the six-stranded parallel β-sheet of the core domain completed by an antiparallel β-strand and the three-stranded antiparallel β-sheet and three α-helices of the cap domain.