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. 2024 Dec 27;13:RP92741. doi: 10.7554/eLife.92741

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© 2024, Tian, Yang, Zhao et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A, B) Higher expression of TIPE was observed in melanoma tumor tissues than in the control, as evidenced by immunohistochemistry. (C, D) The expression of TIPE correlated well with p-PKM2(Ser37) in melanoma tumor tissues. (E) Similarly, a good correlation was observed between TIPE, p-PKM2(Ser37), LDH, and CD44 in mouse xenografts. (F–I) In addition, the expression of TIPE was positively correlated with CSCs markers, including BMI1, NANOG, NOTCH1, and POU5F1 in TCGA dataset. (J) A brief model depicting the functional impact of TIPE on metabolic reprogramming in melanoma. ***p < 0.001. The data represent the means ± SEM of three replicates "*p<0.05.

Figure 7—figure supplement 1. — (A, B) Higher expression of TIPE was observed in melanoma tumor tissues than in the control, as evidenced by immunohistochemistry. (C, D) The expression of TIPE correlated well with p-PKM2(Ser37) in melanoma tumor tissues. (E) Similarly, a good correlation was observed between TIPE, p-PKM2(Ser37), LDH, and CD44 in mouse xenografts. (F–I) In addition, the expression of TIPE was positively correlated with CSCs markers, including BMI1, NANOG, NOTCH1, and POU5F1 in TCGA dataset. (J) A brief model depicting the functional impact of TIPE on metabolic reprogramming in melanoma. ***p < 0.001. The data represent the means ± SEM of three replicates "*p<0.05.