Table 1.

Composition of TRES-NLC formulations consisting of one solid lipid (Dynasan 116) and four liquid lipids (Capryol 90, Lauroglycol 90, Miglyol 810, and Tributyrin) in three different weight ratios, 10:90 (200 mg:1800 mg), 50:50 (1000 mg:1000 mg), or 90:10 (1800 mg:200 mg), where Tween 80 was used in two concentration (0.5% (250 mg) or 1.5% (750 mg)) as a surfactant and SPC-75 (50 mg) as a co-surfactant, and trans-resveratrol (TRES) (50 mg) was employed as the drug to prepare 24 TRES-NLC formulations.

Formulation	Solid Lipid (mg)	Liquid Lipid (mg)	Solid Lipid: Liquid Lipid (w/w)	Tween-80 (%)	Co-Surfactant (mg)	TRES (mg)
F1	Dynasan 116	Capryol 90	10:90	0.5	50	50
F2	Dynasan 116	Capryol 90	10:90	1.5	50	50
F3	Dynasan 116	Capryol 90	50:50	0.5	50	50
F4	Dynasan 116	Capryol 90	50:50	1.5	50	50
F5	Dynasan 116	Capryol 90	90:10	0.5	50	50
F6	Dynasan 116	Capryol 90	90:10	1.5	50	50
F7	Dynasan 116	Lauroglycol 90	10:90	0.5	50	50
F8	Dynasan 116	Lauroglycol 90	10:90	1.5	50	50
F9	Dynasan 116	Lauroglycol 90	50:50	0.5	50	50
F10	Dynasan 116	Lauroglycol 90	50:50	1.5	50	50
F11	Dynasan 116	Lauroglycol 90	90:10	0.5	50	50
F12	Dynasan 116	Lauroglycol 90	90:10	1.5	50	50
F13	Dynasan 116	Miglyol 810	10:90	0.5	50	50
F14	Dynasan 116	Miglyol 810	10:90	1.5	50	50
F15	Dynasan 116	Miglyol 810	50:50	0.5	50	50
F16	Dynasan 116	Miglyol 810	50:50	1.5	50	50
F17	Dynasan 116	Miglyol 810	90:10	0.5	50	50
F18	Dynasan 116	Miglyol 810	90:10	1.5	50	50
F19	Dynasan 116	Tributyrin	10:90	0.5	50	50
F20	Dynasan 116	Tributyrin	10:90	1.5	50	50
F21	Dynasan 116	Tributyrin	50:50	0.5	50	50
F22	Dynasan 116	Tributyrin	50:50	1.5	50	50
F23	Dynasan 116	Tributyrin	90:10	0.5	50	50
F24	Dynasan 116	Tributyrin	90:10	1.5	50	50