Figure 7.

Effect of luteolin on cytoxicity, melanin synthesis, and intracellular tyrosinase activity. Cells were treated with luteolin or 200 nM α-MSH for 72 h, and cell viability (A), melanin content (B), and intracellular tyrosinase activity (C) was assessed. Values are expressed as means ± SEM (n = 3) and statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test. ### p < 0.001, #### p < 0.0001 versus control group and *** p < 0.001, **** p < 0.0001 versus α-MSH treatment group.