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. 2024 Dec 17;25(24):13524. doi: 10.3390/ijms252413524

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Downregulation of ITCH expression grants protection against ox-LDL-induced endothelial injury and dysfunction through FTL modulation. For (A–J), after transfection with ITCH siRNA, cells were further infected with FTL siRNA for 24 h and then treated with ox-LDL for an additional 24 h. (A) Cell viability. (B) LDH release. (C) NO production. (D) Monocyte adhesion. (E) mRNA expression of TNF-α. (F) mRNA expression of IL-6. (G) mRNA expression of IL-1β. (H) Secretion of TNF-α. (I) Secretion of IL-6. (J) Secretion of IL-1β. Results are presented as the mean ± S.D. For (A–J), n = 6 independent experiments. ^# p < 0.05 vs. si-con group, * p < 0.05 vs. ox-LDL+si-con group, ^Δ p < 0.05.