Table 2.

Binding residues and binding interactions of top 10 hits with GLP-1 allosteric site.

Hit No. *	Key Binding Residues and Binding Interactions with GLP-1 Receptor **			Key Binding Residues and Binding Interactions with GLP-1 Peptide **			Additional Binding Residues and Binding Interactions with GLP-1 Receptor **
	Leu 142	Tyr 145	Lys 202	Phe 12	Val 16	Leu 20	Ser 206	Glu 138	Asp 198
1	V	V	S	V	V	V	H	S	V
2	V	V	S	V	V	V	H	S	V
3	V	H	H	V	V	V	V	V	H
4	V	H	S	V	V	V	V	V	H
5	V	V	S	V	V	V	H	V	V
6	V	V	V	V	V	V	V	V	H
7	V	V	S	V	V	V	V	V	V
8	V	C	V	V	V	V	V	-	H
9	V	V	V	V	V	V	V	H	V
10	V	H	S	V	V	V	V	V	V

* Hits are arranged according to their XP score. ** Calculated in kJ/mol.