Fig. 1.

CUS produces anxiety-like behavior in female mice. (A) Schematic representation of the experimental procedure. CUS, chronic unpredictable stress; CUMS, chronic unpredictable mild stress; OFT, Open field test; EPM, Elevated plus-maze test; MBT, Marble-burying test. (B) Representative exploration traces in EPM. (C) Percentage of time spent in the open arms and close arms of EPM (n = 20). (D) Representative locomotion traces in OFT. (E) Number of crossing center in the central area and percentage of distance traveled in the central area of OFT (n = 20). (F) Number of marbles buried in MBT (n = 20). (G)The body weight of the CUS and control mice (n = 20). W, week. *, P < 0.05;**, P < 0.01; ***, P < 0.001.