Table 2.
Number of overlapping loci between CVDs and CeVDs conditioning on a certain RF
| SBP | TG | LDL-C | HDL-C | T2D | BMI | cIMT | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N1 | N2 | N1 | N2 | N1 | N2 | N1 | N2 | N1 | N2 | N1 | N2 | N1 | N2 | ||
| CAD | AS | 23 | 2 | 13 | 1 | 9 | 3 | 12 | 1 | 13 | 0 | 10 | 0 | 14 | 1 |
| AIS | 21 | 2 | 12 | 1 | 11 | 2 | 14 | 1 | 7 | 0 | 8 | 0 | 12 | 1 | |
| MI | AS | 17 | 2 | 7 | 1 | 6 | 3 | 7 | 1 | 10 | 0 | 8 | 0 | 9 | 1 |
| AIS | 17 | 3 | 8 | 1 | 7 | 2 | 10 | 1 | 5 | 0 | 7 | 0 | 10 | 1 | |
| HF | AS | 5 | 1 | 5 | 1 | 3 | 1 | 4 | 1 | 6 | 0 | 5 | 0 | 4 | 0 |
| AIS | 6 | 1 | 6 | 1 | 4 | 1 | 4 | 1 | 5 | 0 | 4 | 0 | 4 | 0 | |
| AF | AS | 8 | 1 | 6 | 2 | 5 | 1 | 6 | 1 | 7 | 0 | 4 | 0 | 5 | 0 |
| AIS | 9 | 1 | 5 | 2 | 4 | 1 | 5 | 1 | 4 | 0 | 3 | 0 | 5 | 1 |
N1, the total number of overlapping loci associated with both CVDs and CeVDs conditioning on a certain RF. N2, the total number of overlapping loci associated with CVDs and CeVDs conditioning on a certain RF further passed the cutoff of MOLOC (PPA ≥ 80%).
MOLOC multiple-trait-colocalization, PPA posterior probability of association, CVDs cardiovascular diseases, CeVDs cerebrovascular diseases, RFs risk factors, CAD coronary artery disease, MI myocardial infarction, HF heart failure, AF atrial fibrillation, AS all stroke, AIS all ischemic stroke, SBP systolic blood pressure, T2D type 2 diabetes, BMI body mass index, TG total triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, cIMT carotid intima-media thickness.