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. 2024 Dec 28;14:31001. doi: 10.1038/s41598-024-82165-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig.1 — kM-RIIIJ elevates intracellular calcium in a subset of proprioceptive DRG neurons. (A). Fluorescent images of DRG cells in primary culture loaded with FURA-2. A subset of these neurons express Td-tomato (labeling proprioceptive DRG neurons). (B). Graph showing the percentage of total neurons in culture that express fluorescent td-tomato. 4% of total neurons were labeled, and about 50% of the labeled neurons respond to the application of kM-RIIIJ. (C). Representative calcium traces from six proprioceptors. X-axis indicates the application of pharmacological stimulus presented during an hour-long experiment. Y-axis represents ratiometric signal from 340 nm/380 nm excitation wavelengths. kM-RIIIJ elevated intracellular calcium levels in a subset of proprioceptors, as exemplified by bottom three traces.