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. 2024 Dec 28;14:31001. doi: 10.1038/s41598-024-82165-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig.4 — Persistent sodium currents in proprioceptors. Cells were subjected to a ramp protocol elevating the membrane potential from -70 mV to + 30 mV at the rate of 2.5 mV/s. As shown, persistent sodium currents (peaked at -20 mV) were observed, which were inhibited by the application of 1 μM tetrodotoxin (blue trace). Data obtained from n = 11 proprioceptive DRG neurons. External solution contains 10 mM TEA and 1 mM 4-AP to obtain maximum density of I_NaP. * p < 0.05, ** p < 0.01, *** p < 0.001 determined by using multiple unpaired t-test.