Figure 7. Schematic diagram summarizing how hypoxia‐induced promotor hypomethylation upregulates VCAN to promote EndMT in endothelial cells.

CpG indicates Cytosine‐phosphate‐Guanine; DNMT, DNA methyltransferase; ECM, extracellular matrix; EndMT, endothelial‐to‐mesenchymal transition; α‐SMA, α‐smooth muscle actin; VCAN, versican; and VE‐cadherin, vascular endothelial cadherin.