Forest plot for subgroup analysis. The subgroups were analyzed on TLR using an adjusted* Cox proportional hazard model. *Adjusted for inclusion year, age, sex, smoking status, diabetes, hypertension, hyperlipidemia, previous heart failure, renal failure, previous myocardial infarction, previous coronary artery bypass graft surgery, indication, number of lesions with ISR, lesion location, use of IVUS or OCT, ACC/AHA lesion classification, ISR‐type (DES‐ISR vs BMS‐ISR), number of previous stents in target lesion (single vs multiple) and time to ISR (Early ISR [<31 days] vs late ISR [31–365 days] vs very late ISR [>365 days]). ACC/AHA indicates American College of Cardiology/American Heart Association; ACS, acute coronary syndrome; BMS, bare‐metal stent; CAD, coronary artery disease; DCB, drug‐coated balloon; DES, drug‐eluting stent; ISR, in‐stent restenosis; IVUS, intravascular ultrasound; OCT, optical coherence tomography; POBA, plain old balloon angioplasty; and TLR, target lesion revascularization.