Table 1.
Integrating metabolomics and transcriptomics for KEGG pathway enrichment and relevant genes
| Pathway | p-Value | Corrected p-value | Gene symbol |
|---|---|---|---|
| Gap junction | 0.038993 | 0.074212 | TUBB6|PDGFD|PRKACB |
| Autophagy—animal | 0.00489 | 0.019897* | IGF1R|DDIT4|EIF2AK3|HIF1A|PRKACB |
| Phosphatidylinositol signaling system | 0.200611 | 0.255915 | PIK3C2B|DGKG |
| Phospholipase D signaling pathway | 0.008727 | 0.028197* | CYTH3|RAPGEF3|PDGFD|DGKG|IGH |
| Sphingolipid signaling pathway | 0.260831 | 0.315672 | S1PR5|TNFRSF1A |
| Choline metabolism in cancer | 0.001694 | 0.010158* | CHPT1|PDGFD|DGKG|HIF1A|FOS |
| Pathways in cancer | 1.37E-05 | 0.000323** | CDKN2B|IGF1R|FOS|GNB4|PRKACB|RXRA|HIF1A|SMAD3|IL6|DLL1|JUP|ARAF|CDK6|IL15|LEF1|MYC |
| Insulin resistance | 0.063329 | 0.104514 | IL6|SOCS3|TNFRSF1A |
| Pathogenic Escherichia coli infection | 0.369197 | 0.410993 | TUBB6 |
| Inositol phosphate metabolism | 0.460569 | 0.485242 | PIK3C2B |
| Metabolic pathways | 0.210821 | 0.263247 | PLD4|CD38|GCNT1|GPT2|AASS|NT5E|HACD1|PIK3C2B|MGAT3|RRM2|CHDH|CHPT1|LARGE1|DGKG|CSGALNACT1 |
| Glycerophospholipid metabolism | 0.04923 | 0.086061 | PLD4|CHPT1|DGKG |
| Glycerolipid metabolism | 0.094317 | 0.147409 | MGAT3|DGKG |
| Ether lipid metabolism | 0.008024 | 0.027446* | PLD4|CHPT1|ENPP2 |
| Sphingolipid metabolism | 0.363591 | 0.415781 | SGPP2 |
| Fat digestion and absorption | 0.048439 | 0.085311 | SCARB1|MGAT3 |
| Vitamin digestion and absorption | 0.185855 | 0.240998 | SCARB1 |
| Regulation of lipolysis in adipocytes | 0.369197 | 0.410993 | PRKACB |
| Retrograde endocannabinoid signaling | 0.036793 | 0.071173 | GNAO1|GABRB2|GNB4|PRKACB |
| Long-term depression | 0.015044 | 0.03859 | GNAO1|IGF1R|ARAF |
The blod values means statistically significant. *p < 0.05, **p < 0.01