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. 2024 Dec 28;43:334. doi: 10.1186/s13046-024-03258-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 12 — Graphic model depicting how in 3D high-grade serous ovarian cancer (HG-SOC) patient-derived spheroid models the ET-1/ET-1R/YAP circuit, intersecting mechanical forces generated by a stiff extracellular matrix (ECM), potentiates the HG-SOC invasive behaviour and sustains PARP inhibitors (PARPi) tolerance. Figure created with biorender.com. Abbreviations: EC_PDO: Patient-derived endometrial cancer organoids, 3D: Three-dimensional. PBMC: Peripheral blood mononuclear cells. TAMs: Tumor-associated macrophages. PDOs: Patient-derived organoids. HNSCC: Head and neck squamous cell carcinoma. ECM: Extracellular matrix