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. 2024 Dec 28;43:334. doi: 10.1186/s13046-024-03258-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 13 — A Workflow of the integrated approach employed to identify determinants of ICB response. Archival tumor tissues, collected at the time of surgery, of a cohort of naïve of treatment NSCLC patients who recurred and were treated with ICB in accordance with guidelines were scored as poor (PR) and good (GR) ICB responders. Spatial transcriptomic by 10XVisium highlighted distinct composition and functionality of TLS of PR versus GR. B Standardization of organotypic tissue slices (TS) obtained from resected naïve of treatment NSCLC patients. TS were sliced, cultured, treated with ICB ex-vivo and then subjected to histological analysis. Figure created with biorender.com