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. 2024 Dec 28;43:334. doi: 10.1186/s13046-024-03258-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TIICs expansion and characterization. A Images representative of one Urachal carcinoma sample mPDO in brightfield and multiplex immunofluorescence (3D passage 1); depicted are cytokeration-7 (red), αSMA (green) and CD45 (magenta). B Images representative of one renal medullary carcinoma sample TIICs in brightfield and multiplex immunofluorescence (passage 1 and 3, respectively); depicted are cytokeration-7 (red), αSMA (green) CD45 (magenta). C Graphical representation of the proportion of cells positive for CD45, Vimentin and Cytokeratin within the parental tumor sample processed analysed via multiplex immunofluorescence. Coral colouring marks the tumours showing TIICs expansion. D Co-culture conditions tested for the medullary renal carcinoma cPDO with autologous PBMCs and TIICs with graphical representation of the organoid growth