Fig. 1.

Epistatic network comparative analysis conceptual flowchart: This study evaluates genetic data using two distinct epistasis models to construct and compare epistatic networks. By employing edge thresholding to enhance network modularity, we construct and compare epistatic networks for the analysis of the complex trait of body mass index (BMI) in rats. Our comparative analysis emphasizes the unique insights gained from enrichment analysis at both network and community levels, alongside the identification of network motifs indicative of higher-order epistasis