Table 3.

Summary of Acute Adverse Events

	Radiation (N=74)		Radiation+Cisplatin (N=76)
Adverse Event (%)	Any Grade	Grade 3–5	Any Grade	Grade 3–5	p-value
	2.8	1.4	14.4	1.3	0.012
Allergy/Immunology	0.0	0.0	2.6	1.3	0.16
Coagulation	0.0	0.0	1.3	0.0	0.32
Constitutional Symptoms	64.9	2.7	82.9	1.3	0.016
Cardiac	15.0	4.1	23.7	7.9	0.16
Dermatology/Skin	28.4	0.0	38.2	2.6	0.28
Endocrine	4.2	1.4	6.6	0.0	0.52
Gastrointestinal	79.7	9.5	71.0	9.2	0.042
Renal/Genitourinary	32.4	2.7	31.6	3.9	0.99
Hemorrhage/Bleeding	10.8	0.0	9.2	1.3	0.76
Blood/Bone Marrow	67.6	12.2	89.5	36.9	<0.001
Infection	8.1	1.4	18.4	1.3	0.07
Lymphatics	10.8	0.0	19.7	1.3	0.11
Musculoskeletal	4.2	0.0	14.5	2.6	0.032
Metabolic/Laboratory	40.5	2.7	61.8	18.4	0.001
Neurology	23.0	0.0	36.8	3.9	0.05
Ocular	0.0	0.0	6.6	0.0	0.025
Pulmonary	16.2	0.0	27.6	2.6	0.08
Pain	47.3	5.4	57.9	0.0	0.89
Sexual/Reproductive	21.7	0.0	11.8	0.0	0.10
Vascular	0.0	0.0	7.9	2.6	0.014

^*P-values for the between-group comparison of the maximum grade of adverse events were calculated with a Kruskal-Wallis test corrected for ties.