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. 2024 Dec 28;14:31306. doi: 10.1038/s41598-024-82760-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Comparison of CRP, Ferritin, and HScore in patients with HLH, AOSD, and CCS. (A) Median CRP was significantly lower in HLH (71, IQR 37–104) compared to AOSD (172, IQR 137, 223, p < 0.001) and CCS (121, IQR 97–172, p = 0.0095). (B) Median serum ferritin levels were significantly lower in CCS (1,386.0 ug/L, IQR 969–2335) compared to HLH (29,019 ug/L, IQR 8,888 − 56,289, p < 0.001) and AOSD (11,359 ug/L, IQR 6,000–14,951, p = 0.014). Median serum ferritin levels were also significantly lower in AOSD compared to HLH (p = 0.0352). (C) Median HScore in HLH was 190 (IQR 158–219) compared to 119 in AOSD (IQR 86–143, p < 0.001) and 87 in CCS (IQR 33–112, p < 0.001).