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. 2024 Dec 28;14:31348. doi: 10.1038/s41598-024-82757-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5. — 5 × 8 Gy SBRT decreases pancreatic tumor hypoxia. (a) Intravital fluorescence microscopy of 5xHRE/GFP-expressing BxPC3 tumor cells show a significant decrease in the GFP mean fluorescence intensity (MFI) 1 day post-SBRT. (b) Representative images and (c) quantification of CA9 staining (brown) in ex vivo BxPC3 tumor tissue sections show a significant decrease in tumor cell hypoxia at both 1 and 14 days post-SBRT, compared to non-irradiated control mice. Tissue sections are counterstained with hematoxylin (blue). Scale bar = 200 μm. n = 7 mice per group. *p < 0.05.