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. 2024 Dec 28;14:31110. doi: 10.1038/s41598-024-82423-6

Table 8.

Pathway and process enrichment analysis of down-regulated differentially expressed genes (Metascape, Access 2023.12.15).

GO Category Description Count % Log10(p) Log10(q)
GO:0007030 GO Biological Processes Golgi organization 9 3.80 − 5.67 − 1.44
R-HSA-72613 Reactome Gene Sets Eukaryotic Translation Initiation 8 3.38 − 5.31 − 1.44
CORUM:1153 CORUM Integrator complex 3 1.27 − 4.01 − 0.73
WP4537 WikiPathways Hippo YAP signaling 3 1.27 − 3.19 − 0.21
GO:0044089 GO Biological Processes Positive regulation of cellular component biogenesis 12 5.06 − 3.14 − 0.21
GO:0009615 GO Biological Processes Response to virus 10 4.22 − 3.05 − 0.17
WP5216 WikiPathways Warburg effect modulated by deubiquitinating enzymes and their substrates 3 1.27 − 2.97 − 0.13
GO:1902455 GO Biological Processes Negative regulation of stem cell population maintenance 3 1.27 − 2.97 − 0.13
GO:0006259 GO Biological Processes DNA metabolic process 15 6.33 − 2.95 − 0.13
GO:0042594 GO Biological Processes Response to starvation 7 2.95 − 2.83 − 0.06
GO:0048515 GO Biological Processes Spermatid differentiation 7 2.95 − 2.82 − 0.06
GO:0033363 GO Biological Processes Secretory granule organization 4 1.69 − 2.79 − 0.06
GO:0051345 GO Biological Processes Positive regulation of hydrolase activity 11 4.64 − 2.77 − 0.05
GO:0071479 GO Biological Processes Cellular response to ionizing radiation 4 1.69 − 2.67 − 0.01
GO:0120035 GO Biological Processes Regulation of plasma membrane bounded cell projection organization 13 5.49 − 2.67 − 0.01
WP3932 WikiPathways Focal adhesion PI3K Akt mTOR signaling pathway 8 3.38 − 2.56 0.00
GO:0050709 GO Biological Processes Negative regulation of protein secretion 4 1.69 − 2.56 0.00
GO:0006109 GO Biological Processes Regulation of carbohydrate metabolic process 6 2.53 − 2.50 0.00
GO:0032570 GO Biological Processes Response to progesterone 3 1.27 − 2.39 0.00
GO:0031647 GO Biological Processes Regulation of protein stability 8 3.38 − 2.37 0.00