Table 2.
Univariate analysis of influencing factors of failure to collect oocytes in training cohort.
| Characteristics | OA (n = 1,343) |
NOA (n = 81 ) |
P |
|---|---|---|---|
| Age (year) | 38.00 (33.00, 42.00) | 39.00 (33.00, 43.00) | 0.457 |
| Infertility type, n (%) | 0.386 | ||
| Primary infertility | 419 (31.20) | 29 (35.80) | |
| Secondary infertility | 924 (68.80) | 52 (64.20) | |
| Infertility duration (year) | 3.00 (1.00, 5.00) | 3.00 (1.00, 5.00) | 0.920 |
| Gravidity | 1.00 (0.00, 3.00) | 1.00 (0.00, 3.00) | 0.886 |
| Parity | 0.00 (0.00, 1.00) | 1.00 (0.00, 1.00) | 0.682 |
| BMI (kg/m2), n (%) | 0.973 | ||
| < 25 | 964 (71.78) | 58 (71.60) | |
| ≥ 25 | 379 (28.22) | 23 (28.40) | |
| Basal FSH (mIU/ml) | 9.57 (7.09, 12.91) | 12.03 (9.91, 19.60) | < 0.001 |
| Basal LH (mIU/ml) | 4.56 (3.31, 6.27) | 5.51 (4.15, 7.83) | < 0.001 |
| Basal E2 (pg/ml) | 38.83 (25.70, 54.92) | 35.14 (20.58, 56.91) | 0.425 |
| Basal P (ng/ml) | 0.31 (0.20, 0.48) | 0.31 (0.19, 0.41) | 0.446 |
| AMH (ng/ml) | 0.50 (0.29, 0.76) | 0.23 (0.10, 0.37) | < 0.001 |
| TSH (μIU/ml) | 2.20 (1.52, 3.09) | 2.14 (1.45, 3.21) | 0.982 |
| AFC | 3.00 (2.00, 4.00) | 2.00 (1.00, 3.00) | 0.001 |
| Infertility diagnosis, n (%) | 0.328 | ||
| Tubal factor | 608 (45.27) | 34 (41.98) | |
| Anovulatory | 5 (0.37) | 0 (0.00) | |
| Endometriosis | 91 (6.78) | 10 (12.35) | |
| Male factor | 88 (6.55) | 7 (8.64) | |
| Unexplained | 551 (41.03) | 30 (37.04) | |
| COS protocol, n (%) | < 0.001 | ||
| Agonist | 805 (59.94) | 15 (18.52) | |
| Antagonist | 411 (30.60) | 30 (37.04) | |
| PPOS | 93 (6.92) | 24 (29.63) | |
| Mild stimulation/natural cycle | 34 (2.53) | 12 (14.81) | |
| Total dose of Gn | 3600.00 (2700.00, 4200.00) | 2700.00 (1800.00, 3600.00) | < 0.001 |
| Duaration of stimulation | 12.00 (10.00, 14.00) | 10.00 (7.00, 12.00) | < 0.001 |
| Fertilization method, n (%) | 0.996 | ||
| IVF | 1094 (81.46) | 66 (81.48) | |
| ICSI | 249 (18.54) | 15 (18.52) | |
| No. of follicles ≥ 14 mm on trigger | 3.00 (2.00, 5.00) | 1.00 (1.00, 1.00) | < 0.001 |
| ∆E2 (pg/ml), n (%) | < 0.001 | ||
| ≥ 150 | 818 (60.91) | 16 (19.75) | |
| < 150 and ≥ 0 | 443 (32.99) | 52 (64.20) | |
| < 0 | 82 (6.11) | 13 (16.05) | |
| ∆LH (mIU/ml) | 0.01 (-0.39, 0.55) | 0.34 (-0.21, 2.40) | 0.004 |
| ∆P (ng/ml) | 0.09 (0.00, 0.22) | 0.04 (-0.04, 0.15) | 0.003 |
Variables were presented as median (interquartile range), or n(%).
BMI = body mass index; FSH = follicle-stimulating hormone; LH = luteinizing hormone; E2 = estradiol; P = progesterone; AMH = anti-Müllerian hormone; TSH = thyroid stimulating hormone; AFC = antral follicle count; COS = controlled ovarian stimulation; PPOS = progestin-primed ovarian stimulation; Gn = gonadotropin; IVF = in vitro fertilization; ICSI = intracytoplasmic sperm injection; ∆E2 = change in E2 level between the day before trigger and the trigger day; ∆LH = change in LH level between the day before trigger and the trigger day; ∆P = change in P level between the day before trigger and the trigger day; OA = oocytes acquired; NOA = no oocytes acquired.