Table 2.
Factors predicting overall survival.
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| HR | p-value | HR | 95% CI | p-value | |
| Sex, male | 1.027 | 0.926 | |||
| Age, > 72 years | 1.724 | 0.023 | 1.272 | 0.760–2.148 | 0.361 |
| HBV infection, yes | 0.801 | 0.462 | |||
| HCV infection, yes | 0.856 | 0.556 | |||
| Number of tumors | 1.500 | 0.006 | |||
| Number of tumors, multiple | 2.079 | 0.006 | 1.611 | 0.904–2.791 | 0.104 |
| Largest tumor size, > 3 cm | 1.939 | 0.008 | 1.547 | 0.890–2.777 | 0.123 |
| Serum AFP level (ng/mL) | 1.575 | 0.808 | |||
| Child–Pugh grade, B | 1.463 | 0.485 | |||
| ALBI grade, II or III | 2.330 | 0.206 | |||
| Microscopic portal vein invasion, +/-, + | 3.325 | < 0.001 | |||
| Microscopic hepatic vein invasion, +/- | 2.323 | 0.079 | |||
| Microvascular invasion, + | 3.611 | < 0.001 | 2.564 | 1.433–4.499 | 0.002 |
| Surgical procedure, major resection | 1.300 | 0.421 | |||
| Anatomic resection | 1.124 | 0.669 | |||
| FLIS, 2–5 | 2.558 | < 0.001 | 1.189 | 1.077–3.226 | 0.027 |
HR hazard ratio, CI confidence interval, HBV Hepatitis B virus, HCV Hepatitis C virus, AFP alpha-fetoprotein, ALBI grade albumin–bilirubin grade, FLIS Functional liver imaging score.