Table 3.
Factors predicting recurrence-free survival.
| Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| HR | p-value | HR | 95% CI | p-value | |
| Sex, male | 0.835 | 0.350 | |||
| Age, > 72 years | 1.261 | 0.163 | |||
| HBV infection, yes | 0.861 | 0.459 | |||
| HCV infection, yes | 0.943 | 0.745 | |||
| Number of tumors | 1.473 | < 0.001 | |||
| Number of tumors, multiple | 2.231 | < 0.001 | 2.103 | 1.414–3.078 | < 0.001 |
| Largest tumor size, > 3 cm | 1.579 | 0.007 | 1.463 | 1.014–2.131 | 0.042 |
| Serum AFP level (ng/mL) | 1.000 | 0.244 | |||
| Child–Pugh grade, B | 1.728 | 0.166 | |||
| ALBI grade, II or III | 1.667 | 0.352 | |||
| Microscopic portal vein invasion, +/-, + | 2.496 | < 0.001 | |||
| Microscopic hepatic vein invasion, +/- | 2.240 | 0.022 | |||
| Microvascular invasion, + | 2.526 | < 0.001 | 1.720 | 1.107–2.616 | 0.017 |
| Surgical procedure, major resection | 1.188 | 0.457 | |||
| Anatomic resection | 0.919 | 0.655 | |||
| FLIS, 2–5 | 1.665 | 0.019 | 1.487 | 0.963–2.237 | 0.073 |
HR hazard ratio, CI confidence interval, HBV Hepatitis B virus, HCV Hepatitis C virus, AFP alpha-fetoprotein, ALBI grade albumin–bilirubin grade, FLIS Functional liver imaging score.