Table 1.

Variables Used in the Drug Binding Model

Symbol	Description	Units
K1	Forward rate constant	ml・sec−1・μCi−1
k2	Reverse rate constant	sec−1
Vi	Volume of compartment i	ml
Ci	Drug concentration in compartment i	μCi ml−1
fi	Drug fraction free from nonspecific binding	None
koff	Reverse rate constant	sec−1
kon	Forward rate constant	ml・sec−1・μCi−1
Bmax	Maximum drug specific binding concentration	μCi ml−1
BP	Binding potential of specific binding	None