TABLE 1.

Model parameters and distribution.

Parameter	Range
	Baseline	Min	Max	Distributed	Source
Cost per dollar
Rituximab 50 mL:0.5 g/bottle	874.03	532.54	1,092.54	Gamma	a
Cyclophosphamide 0.2 g/branch	3.33	3.33	3.35	Gamma	a
Doxorubicin 10 mg/pill	3.10	2.97	3.18	Gamma	a
Vincristine 1 mg/branch	27.08	23.61	38.47	Gamma	a
Prednisone 5 mg/100 tablets	0.85	0.46	1.66	Gamma	a
Lenalidomide 25  mg/21 capsules	84.99	18.41	3,005.97	Gamma	a
Second-line cost	1,292.52	1,034.02	1,551.03	Gamma	a
Examination fee	144.29	115.43	173.15	Gamma	Zhang et al. (2020)
Adverse event handling costs
Neutropenia	1,094.28	875.42	1,313.14	Gamma	Luo et al. (2022)
Thrombopenia	1,415.63	1,132.50	1,698.76	Gamma	Luo et al. (2022)
Anaemia	2,150.12	1,720.10	2,580.14	Gamma	Luo et al. (2022)
Adverse event rate
Incidence of R-CHOP neutropenia	0.54	0.43	0.65	Beta	Nowakowski et al. (2021)
Incidence of R-CHOP thrombocytopenia	0.13	0.10	0.16	Beta	Nowakowski et al. (2021)
Incidence of R-CHOP anemia	0.20	0.16	0.24	Beta	Nowakowski et al. (2021)
Incidence of R2-CHOP neutropenia	0.60	0.48	0.72	Beta	Nowakowski et al. (2021)
Incidence of R2-CHOP thrombocytopenia	0.34	0.27	0.41	Beta	Nowakowski et al. (2021)
Incidence of R2-CHOP anemia	0.29	0.23	0.35	Beta	Nowakowski et al. (2021)
Utility
PFS utility	0.83	0.66	0.99	Beta	Li et al. (2022)
PD utility	0.39	0.31	0.47	Beta	Li et al. (2022)
Discount rate	0.05	0.00	0.08-	-	Gan et al. (2023)

a represent median list price of a drug from a publicly available database.