TABLE 2.

Drug concentrations and clearance results.

Drug	Infusion rate (mg/h)	Added drug (mg)	Eliminated drug (mg/9 h)	Drug removal (%)	CLADVOS [L/h]		CLCRRT [L/h]
					BFR 100 mL/min CFR 160 mL/min DFR 800 mL/min	BFR 200 mL/min CFR 320 mL/min DFR 800 mL/min	BFR 200 mL/h DFR 2 L/h
Anidulafungin	5.1	63	38	61	0.84	0.84	0.02
Cefotaxime	74.9	849	787	93	2.74	4.77	1.34
Daptomycin	74	1,004	787	78	1.04	1.36	0.10
Fluconazole	56	576	540	94	3.39	6.20	1.80
Ganciclovir	23.7	262	246	94	2.91	5.88	1.98
Linezolid	26.8	281	258	92	2.79	4.65	1.38
Meropenem	59.2	595	556	93	3.40	6.08	1.96
Piperacillin	164	1784	1,667	93	3.18	5.61	1.56

Residual CL (renal + non-renal) is neglected for calculation purposes. CRRT, clearance was calculated assuming a dialysate flow rate of 2 L/h. BFR: blood flow rate; CFR: concentrate flow rate; CL: clearance; CRRT: continuous renal replacement therapy; DFR: dialysate flow rate; grey shaded rows indicate drug with protein binding >90%.