TABLE 3.
Dose calculations based on in vitro CLADVOS and calculated CLCRRT.
| Treatment | No extracorporeal support | ADVOS | CRRT | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Settings | BFR 100 mL/min CFR 160 mL/min DFR 800 mL/min | BFR 200 mL/min CFR 320 mL/min DFR 800 mL/min | BFR 200 mL/h DFR 2 L/h | ||||||
| CrCL (mL/min) | >60 | 25 | 0 | 25 | 0 | 25 | 0 | 25 | 0 |
| Dose calculations (mg/24 h) | Standard licensed dose | ||||||||
| Anidulafungin | 100 | 100 | 100 | 180 | 180 | 180 | 180 | 100 | 100 |
| Cefotaxime | 6,000 | 3,080 | 2,100 | 4,070 | 3,090 | 4,810 | 3,830 | 3,560 | 2,590 |
| Daptomycin | 700 | 440 | 360 | 1,630 | 1,550 | 2000 | 1920 | 550 | 470 |
| Fluconazole | 800 | 380 | 240 | 2,780 | 2,640 | 4,770 | 4,630 | 1,660 | 1,520 |
| Ganciclovir | 800 | 260 | 80 | 540 | 360 | 820 | 640 | 450 | 270 |
| Linezolid | 1,200 | 930 | 840 | 1,440 | 1,350 | 1770 | 1,680 | 1,180 | 1,090 |
| Meropenem | 3,000 | 1,310 | 750 | 2,100 | 1,540 | 2,720 | 2,150 | 1770 | 1,200 |
| Piperacillin | 12,000 | 6,420 | 4,050 | 8,640 | 6,540 | 10,880 | 8,780 | 7,150 | 5,040 |
CrCL: creatinine clearance; BFR: blood flow rate; CFR: concentrate flow rate; DFR: dialysate flow rate; grey shaded rows depict drugs requiring higher dosages under ADVOS, compared to standard licensed drug regimens.