Table 4.

Mediation analysis on the association between childhood maltreatment and T2D via BMI.

	Model 1				Model 2
	Estimate	LCIa	UCIb	p-value	Estimate	LCIa	UCIb	p-value
Total effect, HR	1.16	1.14	1.18	<0.001	1.17	1.14	1.20	<0.001
Total natural direct effect, HR	1.11	1.09	1.13	<0.001	1.12	1.09	1.14	<0.001
Pure natural indirect effect, HR	1.05	1.04	1.05	<0.001	1.05	1.04	1.05	<0.001
% of excess risk attributed to:
Interaction with BMI	9.7	1.1	19.0	0.02	8.4	0.8	17.0	0.03
Mediation via BMI	32.4	27.6	39.0	<0.001	31.1	26.0	36.1	<0.001
Total via BMI	42.2	32.8	52.1	<0.001	39.4	32.9	49.2	<0.001

Model 1 adjusted for age, sex, ethnicity, deprivation, education; Model 2 additionally adjusted for physical activity, TV viewing, sleep duration, alcohol consumption and smoking status as exposure-induced mediator-outcome confounders.

^aLCI - Lower 95% confidence interval.

^bUCI - Upper 95% confidence interval.