Figure 3.

Effects of adolescent CRD and adult CRD on natural and cocaine reward. Adolescent CRD also altered sucrose preference, decreasing preference compared to controls in male mice, but not female mice (A). There was no effect of adult CRD (B) on sucrose preference. Adolescent CRD (C), but not adult CRD (D) increased cocaine CPP. Individual data points are shown for each sample with males indicated by gray-filled circles and females by open circles. Mean ± SEM, n = 12–16 for sucrose preference and 16–24 for CPP, *p ≤ 0.05.