Figure 4.

Effects of adolescent CRD on cocaine self-administration. (A) In females, adolescent CRD had no effect on the acquisition of cocaine self-administration (left). There was a trend for an interaction between the effects of adolescent CRD and session on the acquisition of cocaine self-administration in males (middle). Females with adolescent CRD reached the criteria for cocaine self-administration faster than controls (right). (B) Control and adolescent CRD female and male mice self-administered cocaine similarly in a dose–response curve. Mean ± SEM, n = 13–18, *p ≤ 0.05.