TABLE 2.
GO and KEGG pathway analyses of the differentially expressed genes induced by DMOG/hypoxia. Top 10 results are listed along with the P values.
| GO and KEGG terms | P value |
|---|---|
| GO_BP_Direct, WT cells | |
| animal organ development | 1.3E-4 |
| endochondral bone growth | 3.5E-3 |
| cartilage development involved in endochondral bone morphogenesis | 3.5E-3 |
| regulation of blood pressure | 1.7E-2 |
| heart morphogenesis | 1.7E-2 |
| positive regulation of transcription from RNA polymerase II promoter | 2.3E-2 |
| chromatin remodeling | 2.7E-2 |
| negative regulation of cell migration | 3.1E-2 |
| positive regulation of protein complex assembly | 3.1E-2 |
| wound healing | 3.2E-2 |
| GO_BP_Direct, KO cells | |
| mitochondrial translation | 1.2E-9 |
| sphingolipid biosynthetic process | 7.9E-4 |
| lysosome localization | 1.3E-3 |
| cellular response to BMP stimulus | 1.3E-3 |
| carbohydrate derivative biosynthetic process | 1.3E-3 |
| proximal/distal pattern formation | 1.6E-3 |
| natural killer cell activation | 1.6E-3 |
| DNA replication initiation | 2.6E-3 |
| translation | 6.4E-3 |
| canonical glycolysis | 6.6E-3 |
| KEGG, KO cells | |
| Metabolic pathways | 2.8E-5 |
| Glycolysis / Gluconeogenesis | 1.7E-3 |
| Carbon metabolism | 1.8E-2 |
| p53 signaling pathway | 2.7E-2 |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 3.5E-2 |
| RNA degradation | 4.1E-2 |
| HIF-1 signaling pathway | 4.3E-2 |
| Fatty acid elongation | 5.4E-2 |
| Glycosaminoglycan degradation | 5.5E-2 |
| Cell cycle | 6.2E-2 |