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Expression and regulation of SGK1. The transcription of SGK1 mRNA is regulated by extracellular signals (e.g., GF, sodium ions, etc.). Activation of SGK1 is mediated by activation of Thr256 phosphorylated by PI3K/PDK1. In addition, mTORC2 can also phosphorylate SGK1 at Ser422, and phosphorylation of Ser422 also promotes the activation of Thr256.
