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. 2024 Dec 6;17:503–512. doi: 10.1016/j.ibneur.2024.12.003

Table 1.

The pathophysiological role of SGK1 in various neurological disorders.

Neuropathic disease Actions of SGK1 Functional outcomes References
Alzheimer's disease Accelerate Aβ degradation, γ-secretase phosphorylation, Reduction of AD symptoms Mo et al. (2012); Chow et al. (2015); Lian et al. (2020)
Exacerbate tau protein phosphorylation Aggravation of cognitive impairment Elahi et al. (2021)
Parkinson's disease Reduce α-syn levels Reduction of PD-related symptoms Heo et al., 2023, Seo et al., 2023, Yeo and Lim, 2019, Yeo et al., 2018
Activate the NF-κB signaling pathway Exacerbation of neuroinflammation Kwon et al. (2021)
Epilepsy Accelerate NEDD4–2 degradation seizure aggravation Kim et al. (2021b)
Elevate glucose transporter protein levels and
increase Lofora vesicle production
LD aggravation Singh et al. (2013)
PTSD Up-regulate activation of Rab4 protein Reduction of cognitive impairment Yuen et al. (2011)
Stroke Activate the FOXO3a/CREB signaling pathway Reduction of ischemic brain damage Chen et al. (2023)
Decrease the expression of beclin−1, LC−3 Protection of the cerebral nerves Wang et al. (2019)
Regulate Ndrg1-SOX10 axis Aggravation of nerve damage (Wu et al., 2024)
Increase in Na + -K + −2Cl- cotransporter protein abundance Destruction of the BBB Zhang et al. (2015)
Neuropathic pain Enhance spinal ATP release Increasing neuropathic pain Koyanagi et al. (2016); Zhang et al. (2019)Yasukochi et al. (2021)
Mediate NEDD4–2 phosphorylation to upregulate Nav1.7 Liu et al. (2021)
Enhance interaction with kalirin Peng et al. (2013)
Up-regulate HDAC4 phosphorylation Lin et al. (2015)
Major depressive disorder Regulate GR phosphorylation Aggravate MDD Anacker et al., 2013, Cattaneo and Riva, 2016
Aggravate oligodendrocyte overdifferentiation Miyata et al., 2015, Miyata et al., 2016
Huntington's disease Regulate NMDA receptor expression Striatalneuro-
degeneration in HD
Ehrlich, 2012, Zeron et al., 2001
Chorea acanthocytosis Up-regulates ORAI1/STIM1 expression Inhibition of neuronal apoptosis Lang et al. (2018)
Multiple sclerosis Exacerbate oxidative stress Exacerbation of MS disease Wang et al. (2017)

AD: alzheimer's disease; PD: parkinson's disease; LD: lafora disease; PTSD: post-traumatic stress disorder; BBB: blood brain barrier; HD: huntington's disease; MS: multiple sclerosis.

MDD: major depressive disorder;GR: glucocorticoid receptor