Table 1.
Neuropathic disease | Actions of SGK1 | Functional outcomes | References |
---|---|---|---|
Alzheimer's disease | Accelerate Aβ degradation, γ-secretase phosphorylation, | Reduction of AD symptoms | Mo et al. (2012); Chow et al. (2015); Lian et al. (2020) |
Exacerbate tau protein phosphorylation | Aggravation of cognitive impairment | Elahi et al. (2021) | |
Parkinson's disease | Reduce α-syn levels | Reduction of PD-related symptoms | Heo et al., 2023, Seo et al., 2023, Yeo and Lim, 2019, Yeo et al., 2018 |
Activate the NF-κB signaling pathway | Exacerbation of neuroinflammation | Kwon et al. (2021) | |
Epilepsy | Accelerate NEDD4–2 degradation | seizure aggravation | Kim et al. (2021b) |
Elevate glucose transporter protein levels and increase Lofora vesicle production |
LD aggravation | Singh et al. (2013) | |
PTSD | Up-regulate activation of Rab4 protein | Reduction of cognitive impairment | Yuen et al. (2011) |
Stroke | Activate the FOXO3a/CREB signaling pathway | Reduction of ischemic brain damage | Chen et al. (2023) |
Decrease the expression of beclin−1, LC−3 | Protection of the cerebral nerves | Wang et al. (2019) | |
Regulate Ndrg1-SOX10 axis | Aggravation of nerve damage | (Wu et al., 2024) | |
Increase in Na + -K + −2Cl- cotransporter protein abundance | Destruction of the BBB | Zhang et al. (2015) | |
Neuropathic pain | Enhance spinal ATP release | Increasing neuropathic pain | Koyanagi et al. (2016); Zhang et al. (2019); Yasukochi et al. (2021) |
Mediate NEDD4–2 phosphorylation to upregulate Nav1.7 | Liu et al. (2021) | ||
Enhance interaction with kalirin | Peng et al. (2013) | ||
Up-regulate HDAC4 phosphorylation | Lin et al. (2015) | ||
Major depressive disorder | Regulate GR phosphorylation | Aggravate MDD | Anacker et al., 2013, Cattaneo and Riva, 2016 |
Aggravate oligodendrocyte overdifferentiation | Miyata et al., 2015, Miyata et al., 2016 | ||
Huntington's disease | Regulate NMDA receptor expression | Striatalneuro- degeneration in HD |
Ehrlich, 2012, Zeron et al., 2001 |
Chorea acanthocytosis | Up-regulates ORAI1/STIM1 expression | Inhibition of neuronal apoptosis | Lang et al. (2018) |
Multiple sclerosis | Exacerbate oxidative stress | Exacerbation of MS disease | Wang et al. (2017) |
AD: alzheimer's disease; PD: parkinson's disease; LD: lafora disease; PTSD: post-traumatic stress disorder; BBB: blood brain barrier; HD: huntington's disease; MS: multiple sclerosis.
MDD: major depressive disorder;GR: glucocorticoid receptor