Summary of findings 5. Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for miscarriage rate.
| Embryo culture with low oxygen concentration compared to embryo culture with atmospheric oxygen concentration for miscarriage rate | ||||||
| Patient or population: patients with miscarriage rate Settings: Assisted reproductive technologies Intervention: Embryo culture with low oxygen concentration Comparison: embryo culture with atmospheric oxygen concentration | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Embryo culture with atmospheric oxygen concentration | Embryo culture with low oxygen concentration | |||||
| Miscarriage rate | 75 per 1000 | 94 per 1000 (65 to 133) | OR 1.28 (0.86 to 1.9) | 1291 (3 studies) | ⊕⊕⊝⊝ low1,2 | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 One trial had no allocation concealment and another trial did not detail the method of allocation concealment 2 The summary effect crosses the line of no effect and substantive benefit or harm