TABLE 3.

Performance of total EVs vs placental EV markers in predicting pregnancy complications.

Comparison	Name or ratios	AUC	p Value	Sensitivity at fixed specificity
				80%	90%
TD vs PE	Total CD82/Placental‐CD9	0.73	0.023	0.66	0.40
	Total CD62E/P/Placental‐CD9	0.74	0.029	0.49	0.38
	Total CD82/Placental‐TNF RII	0.71	0.029	0.53	0.27
	Total CD82/Placental‐PP13 (2)	0.74	0.034	0.53	0.27
	Total CD82/Placental‐LFA‐1	0.69	0.035	0.53	0.20
	Total PP13 (1)/Placental‐TNF RII	0.69	0.037	0.40	0.40
	Total CD82/Placental‐CD62E/P	0.70	0.038	0.67	0.20
	Total TNF RII/Total CD82	0.71	0.038	0.40	0.33
	Total CD82/Placental‐CD63	0.70	0.039	0.40	0.33
	Total CD82/Placental‐CD81	0.70	0.040	0.56	0.33
	Total CD62E/P/Placental‐TNF RII	0.66	0.042	0.42	0.33
	Total Glypican‐1/Total CD82	0.69	0.044	0.53	0.20
	Total CD62E/P/Total TNF RII	0.63	0.045	0.41	0.33
	Total PP13 (1)/Placental‐CD9	0.72	0.046	0.53	0.27
	Total CD62E/P/Placental‐LFA1	0.64	0.048	0.41	0.33
TD vs PTD	Total CD82/Placental‐Alix	0.80	0.007	0.67	0.40
	Total C1q/Total CD82	0.79	0.006	0.67	0.40
	Total CD82/Placental‐CD9	0.79	0.014	0.70	0.60
	Total CD82/Placental‐TNF RII	0.78	0.007	0.69	0.60
	Total CD82/Placental‐PP13 (3)	0.78	0.009	0.60	0.47
	Total CD82/Placental‐C1q	0.78	0.015	0.73	0.27
	Total CD82/Placental‐CD62E/P	0.77	0.006	0.69	0.67
	Total CD82/Placental‐CD82	0.76	0.027	0.65	0.07
	Total CD63/Placental‐PP13 (3)	0.76	0.018	0.73	0.33
	Total CD82/Placental‐PP13 (2)	0.76	0.019	0.60	0.40
	Total CD82/Placental‐CD63	0.76	0.022	0.51	0.43
	Total CD62E/P/Total C1q	0.76	0.028	0.53	0.43
	Total TNF RII/Total CD82	0.74	0.016	0.67	0.47
	Total CD82/Placental‐VEGFR2	0.74	0.022	0.69	0.13
	Total CD82/Placental‐CD81	0.73	0.021	0.60	0.55
	Total PLAP (2)/Total CD82	0.73	0.034	0.60	0.27
	Total ICAM‐1/Total CD82	0.72	0.013	0.60	0.60
	Total Glypican‐1/Total CD82	0.72	0.024	0.67	0.40
	Total CD82	0.70	0.047	0.67	0.20
PE vs PTD	Total CD81/Placental‐C1q	0.79	0.021	0.40	0.40
	Total C1q/Total PP13 (2)	0.64	0.025	0.40	0.33
	Total CD63/Placental‐PP13 (3)	0.70	0.034	0.40	0.20