Skip to main content
. 2024 Dec 10;9(51):50269–50280. doi: 10.1021/acsomega.4c06271

Table 3. Optimization Study of the Reaction Conditions for the Deprotection of Aryl Estersa.

graphic file with name ao4c06271_0016.jpg

Entry Catalyst Solvent Temperature °C % Yieldb
1   ethanol 60  
2 no catalyst acetonitrile 80  
3   chlorobenzene 130  
4 MCM-41 ethanol 60  
5 acetonitrile 80  
6 chlorobenzene 130  
7 InCl3 ethanol 60  
8 acetonitrile 80 42
9 chlorobenzene 130 62
10 10% InCl3/MCM-41 ethanol 60  
11 acetonitrile 80 36
12 chlorobenzene 130 52
13 15% InCl3/MCM-41 ethanol 60  
14 acetonitrile 80 48
15 chlorobenzene 130 64
16 20% InCl3/MCM-41 ethanol 60  
17 acetonitrile 80 60
18 chlorobenzene 130 85
a

Reaction conditions: 3,5-dimethylphenyl propionate (0.178 g, 1 mmol), chlorobenzene (5 mL), catalyst (100 mg), and reflux 6–8 h.

b

Isolated yields.